The effects of Artvigil 150 mg normally last 12 to 15 hours; however, the medication usually stays in your system for 36 to 72 hours. About 15 hours is its half-life, which indicates how long it takes for half of the dosage to be removed. It typically takes three to four days, or five to seven half-lives, for the body to completely remove it. Age, liver function, metabolism, and dose are among of the variables that might affect how long Artvigil remains in your body.